\u3068\u8a00\u3044\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u307d\u3063\u3053\u308a\u304a\u8179\u3092\u305d\u306e\u307e\u307e\u306b\u3057\u3066\u304a\u304f\u3068\u3001<\/p>\n
\u5fc3\u7b4b\u6897\u585e\u3084\u8133\u6897\u585e\u306a\u3069\u306e\u547d\u306b\u304b\u304b\u308f\u308b\u75c5\u306b<\/strong><\/span><\/p>\n \u3064\u306a\u304c\u3063\u3066\u3057\u307e\u3046<\/strong><\/span>\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n \u4e2d\u6027\u8102\u80aa\u3092\u6e1b\u3089\u3057\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u7570\u5e38\u3092<\/p>\n \u6574\u3048\u308b\u305f\u3081\u306e\u57fa\u672c\u3068\u306a\u308b\u306e\u304c\u98df\u751f\u6d3b<\/strong><\/span>\u3067\u3059\u3002<\/p>\n \u5185\u81d3\u8102\u80aa\u3092\u843d\u3068\u3059\u306b\u306f\u3001\u7cd6\u8cea\u3092\u63a7\u3048\u3001<\/strong><\/span><\/p>\n \u305f\u3093\u3071\u304f\u8cea\u3092\u7a4d\u6975\u7684\u306b\u6442\u308b\u3053\u3068\u304c\u3068\u3066\u3082\u5927\u5207<\/strong><\/span>\u3067\u3059\u3002<\/p>\n <\/p>\n \u305d\u3082\u305d\u3082\u7cd6\u8cea\u3068\u306f\u3001\u5185\u81d3\u8102\u80aa\u306e\u539f\u6599\u3068\u306a\u308b<\/p>\n \u4e2d\u6027\u8102\u80aa\u306e\u5143\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n \u4eba\u9593\u304c\u751f\u547d\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b<\/p>\n \u5fc5\u8981\u3068\u3059\u308b\u6804\u990a\u7d20\u306e\u3046\u3061\u300c\u7cd6\u8cea\u300d<\/strong><\/span>\u3060\u3051\u304c\u3001<\/p>\n \u8840\u6db2\u4e2d\u306e\u7cd6\u306e\u91cf<\/strong>\u300c\u8840\u7cd6\u5024\u300d<\/strong><\/span>\u3092<\/strong><\/p>\n \u4e0a\u6607\u3055\u305b\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/strong><\/p>\n <\/p>\n \u8840\u7cd6\u5024\u304c\u4e0a\u304c\u308b\u3068\u3001\u305d\u308c\u3092\u4e0b\u3052\u308b\u305f\u3081\u306b\u3001<\/strong><\/p>\n \u30db\u30eb\u30e2\u30f3\u306e\u4e00\u7a2e\u3067\u3042\u308b\u300c\u30a4\u30f3\u30b9\u30ea\u30f3\u300d\u304c\u5206\u6ccc\u3055\u308c\u3001<\/strong><\/span><\/p>\n \u8840\u6db2\u4e2d\u306e\u3042\u307e\u3063\u305f\u7cd6\u3092\u8102\u80aa\u306b\u3057\u3066\u84c4\u3048\u308b\u306e\u3067\u3059\u3002<\/strong><\/span><\/p>\n \u8840\u7cd6\u5024\u3092\u6025\u6fc0\u306b\u4e0a\u3052\u3055\u3048\u3057\u306a\u3051\u308c\u3070\u3001<\/p>\n \u4f53\u306b\u4e2d\u6027\u8102\u80aa\u304c\u305f\u307e\u308a\u306b\u304f\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n \u3064\u307e\u308a\u3001\u7cd6\u8cea\u3092\u63a7\u3048\u308b\u3053\u3068\u304c\u3001<\/p>\n \u5185\u81d3\u8102\u80aa\u3092\u843d\u3068\u3059\u30b3\u30c4\u3067\u3059\u3002<\/p>\n \u6ce8\u610f\u3059\u3079\u304d\u306f\u30ab\u30ed\u30ea\u30fc\u3067\u306f\u306a\u304f\u3001<\/strong>\u7cd6\u8cea\u306e\u91cf<\/strong><\/span>\u3067\u3059\u3002<\/strong><\/p>\n <\/p>\n \u7cd6\u8cea\u5236\u9650\u30c0\u30a4\u30a8\u30c3\u30c8\u4e2d\u306e\u5916\u98df\u6642\u30eb\u30fc\u30eb\u306f\u3001<\/p>\n \u300c\u305f\u3093\u3071\u304f\u8cea\uff08\u5375\u30fb\u8089\u30fb\u9b5a\u306a\u3069\uff09\u300d<\/p>\n \u2193<\/p>\n \u5408\u9593\u306b\u300c\u98df\u7269\u7e4a\u7dad\uff08\u91ce\u83dc\u30fb\u304d\u306e\u3053\u306a\u3069\uff09\u300d<\/p>\n \u2193<\/p>\n \u300c\u6c34\u5206\uff08\u307f\u305d\u6c41\u3084\u30b9\u30fc\u30d7\u306a\u3069\uff09\u300d<\/p>\n \u2193<\/p>\n \u300c\u7cd6\u8cea\uff08\u3054\u306f\u3093\u30fb\u30d1\u30f3\u30fb\u3081\u3093\u985e\u306a\u3069\uff09\u3092<\/p>\n \u610f\u8b58\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n <\/p>\n \u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb<\/strong><\/span>\u306b\u306f\u3001<\/p>\n \u7cd6\u306e\u5438\u53ce\u3092\u3086\u308b\u3084\u304b\u306b\u3059\u308b<\/strong><\/span><\/p>\n \u300c\u30aa\u30ec\u30a4\u30f3\u9178\u300d\u304c\u8c4a\u5bcc\u3067\u3059\u3002<\/strong><\/span><\/p>\n \u7cd6\u8cea\u3068\u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u3092\u4e00\u7dd2\u306b\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001<\/p>\n \u98df\u5f8c\u8840\u7cd6\u5024\u306e\u6025\u4e0a\u6607\u3092\u9632\u304e\u3001<\/p>\n \u8102\u80aa\u3092\u305f\u307e\u308a\u306b\u304f\u304f\u3059\u308b<\/strong><\/span>\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n \u307e\u305f\u3001\u30aa\u30ec\u30a4\u30f3\u9178\u306b\u306f\u3001<\/p>\n \u6574\u8178\u4f5c\u7528\u3084\u6297\u9178\u5316\u4f5c\u7528\u3001<\/strong><\/span><\/p>\n \u60aa\u7389\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6e1b\u3089\u3059<\/strong><\/span>\u3068\u3044\u3063\u305f<\/p>\n \u50cd\u304d\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n <\/p>\n \u5348\u5f8c10\u6642\u301c\u5348\u524d2\u6642\u306f\u3001<\/p>\n \u8102\u80aa\u306e\u5408\u6210\u3092\u4fc3\u3057\u3066\u8102\u80aa\u7d30\u80de\u3092<\/p>\n \u751f\u307f\u51fa\u3059\u50cd\u304d\u304c\u3042\u308b\u300cBMAL1\uff08\u30d3\u30fc\u30de\u30eb\u30ef\u30f3\uff09\u300d<\/p>\n \u3068\u3044\u3046\u305f\u3093\u3071\u304f\u8cea\u304c\u5897\u3048\u308b\u6642\u9593\u5e2f\u3067\u3059\u3002<\/p>\n \u300cBMAL1\u300d\u304c\u591a\u3044\u591c\u306e\u9593\u306b\u305f\u304f\u3055\u3093\u98df\u3079\u308b\u3068\u3001<\/p>\n \u305d\u308c\u306b\u3068\u3082\u306a\u3063\u3066\u4e2d\u6027\u8102\u80aa\u3082<\/p>\n \u5897\u3048\u3084\u3059\u304f\u306a\u308b\u306e\u3067\u3001<\/p>\n \u3067\u304d\u308c\u3070\u591c7\u6642\u307e\u3067\u306b\u5915\u98df\u3092<\/p>\n \u6e08\u307e\u305b\u308b\u306e\u304c\u7406\u60f3\u3067\u3059\u3002<\/p>\n <\/p>\n \u809d\u81d3\u304c\u30a2\u30eb\u30b3\u30fc\u30eb\u3092\u5206\u89e3\u3059\u308b\u305f\u3081\u306b<\/strong><\/span><\/p>\n \u7cd6\u3092\u5fc5\u8981\u3068\u3057\u307e\u3059\u3002<\/strong><\/span><\/p>\n \u304a\u9152\u3092\u98f2\u3080\u3068\u809d\u81d3\u306b\u84c4\u7a4d\u3057\u3066\u3044\u305f\u7cd6\u304c<\/p>\n \u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u3057\u3066\u4f7f\u308f\u308c\u3001<\/p>\n \u6b21\u306e\u65e5\u306e\u671d\u306b\u306f\u8840\u7cd6\u5024\u304c\u4e0b\u304c\u308a\u3001<\/p>\n \u4e2d\u6027\u8102\u80aa\u3082\u6e1b\u3063\u3066\u3044\u304f\u306e\u3067\u3059\u3002<\/p>\n \u3057\u304b\u3082\u3001\u809d\u81d3\u306e\u7cd6\u304c\u6e1b\u308b\u3053\u3068\u3067\u3001<\/p>\n \u809d\u81d3\u81ea\u4f53\u3082\u5143\u6c17\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n <\/p>\n \u3067\u306f\u3001\u304a\u3059\u3059\u3081\u30e1\u30cb\u30e5\u30fc\u3092\u307f\u3066\u3044\u304d\u307e\u3057\u3087\u3046\u3002<\/p>\n <\/p>\n <\/p>\n \u5e73\u65e5\u306e\u30e9\u30f3\u30c1\u306f\u307b\u3068\u3093\u3069\u5916\u98df\u3001<\/p>\n \u591c\u3082\u304a\u4ed8\u304d\u5408\u3044\u3067\u307b\u3068\u3093\u3069\u5916\u98df<\/p>\n \u3068\u3044\u3046\u6642\u3082\u591a\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n <\/p>\n \u5916\u98df\u3067\u7cd6\u8cea\uff08\u3054\u306f\u3093\u3084\u3081\u3093\u985e\u306a\u3069\u306e\u4e3b\u98df\uff09\u3092<\/p>\n \u63a7\u3048\u308b\u306e\u306b\u6d3b\u7528\u3057\u305f\u3044\u306e\u304c\u3001<\/p>\n \u5358\u54c1\u3067\u6ce8\u6587\u3067\u304d\u3001\u4e3b\u98df\u3092\u30ab\u30c3\u30c8\u3057\u3084\u3059\u3044<\/p>\n \u30d5\u30a1\u30df\u30ea\u30fc\u30ec\u30b9\u30c8\u30e9\u30f3\u3001<\/p>\n \u305d\u3057\u3066\u7cd6\u8cea\u30aa\u30d5\u30e1\u30cb\u30e5\u30fc\u304c\u5145\u5b9f\u3057\u305f<\/p>\n \u725b\u4e3c\u30c1\u30a7\u30fc\u30f3\u5e97\u3067\u3059\u3002<\/p>\n \u725b\u4e3c\u30c1\u30a7\u30fc\u30f3\u5e97\u306e\u300c\u677e\u5c4b\u300d\u3067\u306f\u3001<\/p>\n \u5b9a\u98df\u306e\u3054\u306f\u3093\u3092\u30d7\u30e9\u30b950\u5186\u3067<\/p>\n \u300c\u8c46\u8150\u30e1\u30cb\u30e5\u30fc\u300d\u306b\u5909\u66f4\u3067\u304d\u307e\u3059\u3002<\/p>\n<\/div>\n \u300c\u3059\u304d\u5bb6\u300d\u306b\u306f\u3001\u3054\u306f\u3093\u306e\u4ee3\u308f\u308a\u306b<\/p>\n \u8c46\u8150\u3092\u4f7f\u7528\u3057\u305f\u4f4e\u7cd6\u8cea\u30e1\u30cb\u30e5\u30fc\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n<\/div>\n \u300c\u5409\u91ce\u5bb6\u300d\u306b\u306f\u725b\u8089\u3068\u9d8f\u8089\u3001\u30d6\u30ed\u30c3\u30b3\u30ea\u30fc\u3001<\/p>\n \u534a\u719f\u5375\u3092\u4f7f\u7528\u3057\u305f\u300c\u9ad8\u305f\u3093\u3071\u304f\u8cea\u3001\u4f4e\u7cd6\u8cea\u300d\u306e<\/p>\n \u30b5\u30e9\u30c0\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<\/div>\n \u3044\u305a\u308c\u3082\u3001\u8089\u3067\u305f\u3093\u3071\u304f\u8cea\u3092\u6442\u308a\u306a\u304c\u3089\u3001<\/strong><\/span><\/p>\n \u3057\u3063\u304b\u308a\u7cd6\u8cea\u3092\u63a7\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b<\/strong><\/span><\/p>\n \u304a\u5f79\u7acb\u3061\u30e1\u30cb\u30e5\u30fc\u3067\u3059\u3002<\/p>\n <\/p>\n <\/p>\n \u30b3\u30f3\u30d3\u30cb\u306e\u98df\u54c1\u306e\u30e1\u30ea\u30c3\u30c8\u306f\u3001<\/p>\n \u88cf\u30e9\u30d9\u30eb\u306b\u539f\u6750\u6599\u540d\u3084\u30ab\u30ed\u30ea\u30fc\u3001<\/p>\n \u6804\u990a\u6210\u5206\u304c\u5168\u90e8\u66f8\u3044\u3066\u3042\u308b\u3053\u3068\u306b\u3042\u308a\u307e\u3059\u3002<\/p>\n <\/p>\n \u3057\u3063\u304b\u308a\u30c1\u30a7\u30c3\u30af\u3057\u3066\u3001<\/p>\n \u30ab\u30ed\u30ea\u30fc\u3092\u6c17\u306b\u3059\u308b\u3060\u3051\u3067\u306f\u306a\u304f\u3001<\/strong><\/span><\/p>\n \u8cea\u306e\u9ad8\u3044\u6804\u990a\u3092\u6442\u308b\u3088\u3046\u306b\u3057\u307e\u3057\u3087\u3046\u3002<\/strong><\/span><\/p>\n \u304a\u3059\u3059\u3081\u306e\u30b3\u30f3\u30d3\u30cb\u98df\u54c1\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n <\/p>\n 1.\u30bb\u30d6\u30f3\uff0d\u30a4\u30ec\u30d6\u30f3\u306e<\/p>\n \u300c\u30b5\u30e9\u30c0\u30d5\u30a3\u30c3\u30b7\u30e5\u300d\u30b7\u30ea\u30fc\u30ba<\/strong><\/span><\/p>\n<\/div>\n \u9752\u9b5a\u306b\u306f\u826f\u8cea\u306a\u8102\u304c\u305f\u3063\u3077\u308a\u542b\u307e\u308c\u3066\u3044\u3066<\/strong><\/span><\/p>\n \u8102\u80aa\u71c3\u713c\u52b9\u679c\u3092\u9ad8\u3081\u3066\u304f\u308c\u307e\u3059\u3002<\/strong><\/span><\/p>\n <\/p>\n 2.\u30d5\u30a1\u30df\u30ea\u30fc\u30de\u30fc\u30c8\u306e<\/p>\n \u300c\u30b5\u30e9\u30c0\u30c1\u30ad\u30f3\u30d0\u30fc \u30d6\u30e9\u30c3\u30af\u30da\u30c3\u30d1\u30fc\u300d<\/strong><\/span><\/p>\n<\/div>\n 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